Collagen Peptides for joint and bone health

Collagen Peptides for joint and bone health

The efficacy of collagen peptides in supporting joint health is supported by an extensive body of scientific studies. Safe and natural, collagen peptides are the body’s own building blocks for cartilage, and an ideal health supplement not only for the older generation but also those who frequently engage in repetitive sports such as running or cycling. 'Collagenx' collagen peptides offer unique and well demonstrated benefits and are increasingly used as the key active ingredient in successful joint health product formulations. 


CollagenX hydrolysed collagen contains 18 amino acids, the building blocks of our tissues and the primary component of proteins. Glycine, proline and hydroxyproline represent around 50% of Collagenx hydrolysed collagen total amino acid content; the glycine and proline concentration in our hydrolysed collagen is 10 to 20 times higher than in other proteins. As a result, Collagenx hydrolysed collagen offers health benefits that cannot be found in other protein sources.

Collagen is the key structural component of cartilage tissue and maintaining sufficient levels is essential to maintain healthy and flexible joints. The efficacy of Collagenx collagen peptides and the mechanism behind its ability to support and improve joint function and joint comfort is backed by scientific studies.

Maintaining healthy joints

In a randomised, placebo-controlled, double-blind clinical trial1, 94 women aged 40-70 with knee joint problems (osteoarthritis classification: 0-III) received 8g of CollagenX hydrolysed collagen or a placebo daily for a period of 6 months. 
  • The WOMAC score is the international standard method for assessing joint health clinically in patients
  • Collagenx hydrolysed collagen treatment resulted in a statistically significant reduction in the WOMAC score by a -22% linked to a 32% decrease in joint pain and 44% improvement of stiffness (subscale scores).


Improving Joint Function

The same study also sought to discover whether  Collagenx Hydrolysed Collagen could improve knee joint function in the same group of women.
  • The Lysholm score is linked to improved knee movement in everyday activities,
  • Collagenx Hydrolysed Collagen treatment resulted in a statistically significant increase of the Lysholm score by 7% which demonstrates the improvements over time.    


Stimulating Chondrocytes (cartilage cells)

In an in vitro study2, primary cartilage cells (chondrocytes) were cultured in the presence of different concentrations of  Collagenx Hydrolysed Collagen for 8 days to demonstrate  Collagenx Hydrolysed Collagen ability to induce the production of the key cartilage components, aggrecan and type 2 collagen, which make up joint tissue.
  • CollagenX Hydrolysed Collagen treatment clearly stimulated the expression of aggrecan and type 2 collagen by the joint cells.


Cartilage-regenerative and anti-inflammatory effects of Collagenx

A new in vivo study3 confirms  Collagenx Hydrolysed Collagen role in supporting joint health, providing scientific documentation of the mechanisms behind cartilage regeneration and joint inflammation reduction.  Collagenx Hydrolysed Collagen is:
  • Cartilage-regenerative - 
     it preserves cartilage area during osteoarthritis      development
  • Chondro-regenerative  - it stimulates chondrocyte proliferation (increased number) and stimulates proteoglycan synthesis.
  • Anti-inflammatory  - it normalises synovial thickness and reduce production of the inflammatory marker TNF.


Bone Health

Bones are living tissues which undergo remodelling, a process which is important to maintain balance to ensure healthy bone mass density and avoid fractures throughout our lives. Collagen provides the organic framework in bones on which minerals are deposited and also contribute to bone flexibility and strength.

Calcium, vitamin D and protein are the key bone health nutrients. Collagen is essential for improving bone flexibility, which helps bones absorb impact. As a pure protein, CollagenX collagen peptides work together with calcium and vitamin to support bone health.

In a survey conducted by the US Council for Responsible Nutrition in the US, it was found that 29% of respondents take supplements to improve their bone health, 36% of those were over the age of 55. Younger audiences are also looking to protect their bones preventatively, the survey reported that 17% of those who replied were aged between 18 and 34, and 31% were between 35 and 54.

Supplements with collagen peptides can strengthen bones as documented in multiple in vitro, in vivo and clinical trials4,5,6,7. Peptan Research has shown that Collagenx collagen peptides can stimulate the endogenous production of collagen in bone tissue, triggering osteoblasts (bone formation cells) and increasing bone size and firmness.


Restoring Bone Mineral Density

In an in vivo study3 an established model that mimics the loss of bone mass (osteopenia) in postmenopausal women (Ovx) was used to investigate the effect of Collagenx Hydrolysed Collagen supplements– the experimental group (Ovx + Collagenx) received a daily dose of Collagenx Hydrolysed Collagen for 3 months in addition to a normal diet (with adequate level of calcium, protein and Vitamin D). The Ovx and Control group received a normal diet only.
  • Collagenx Hydrolysed Collagen treatment restored bone mineral density (BMD) in the experimental group to the normal level. In contrast, the control group had a reduced BMD. 


Improving Bone Strength

The same study as above also investigated the microarchitecture and strength of the bones and demonstrated the following:
  • Collagenx Hydrolysed Collagen treatment increases ultimate bone strength compared to the control group. 


Stimulating Osteoblasts (bone cells)

The mechanisms behind  Collagenx Hydrolysed Collagen bone health benefits are well known. As an example,  Collagenx Hydrolysed Collagen was compared to a control protein in the in vitro study4, referred to below, primary bone cells were cultured in the presence of  Collagenx Hydrolysed Collagen for 2 weeks.
  • Collagenx Hydrolysed Collagen treatment promoted the formation of bone-forming cells (osteoblasts) and stimulated their activity. In contrast, the presence of bone-resorbing cells (osteoclasts) was suppressed. The control protein (BSA) did not show the same effect.



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  • Hi Gerald, I have exactly the same condition. I have been taking the bovine collagen for around 6 years now and I take it every day. Its been a great help. Before taking collagen regularly, my knee would ‘blow up’ after a walk so much so that it would be stiff and swollen. Although I still have discomfort when going up and down stairs, I do not have the stiffness or swelling, and pain is much less. I still complete a 5k beach walk most days with no knee problem.

    collagenx on
  • Which product is best for helping knee pain caused by bone on bone?

    Gerald Otten on

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